Location of Ryanodine and Dihydropyridine Receptors in Frog Myocardium
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چکیده
منابع مشابه
Bi-directional coupling between dihydropyridine receptors and ryanodine receptors.
The control of calcium signaling between plasma membrane dihydropyridine receptors (DHPRs or L-type calcium channels) and ryanodine receptors (RyRs or calcium release channels) located in the endoplasmic/sarcoplasmic reticulum (ER/SR) underlies a broad array of functions including skeletal muscle contraction, cardiac performance, arteriole tone, neurosecretion, synaptic plasticity, and gene reg...
متن کاملActivation of purified cardiac ryanodine receptors by dihydropyridine agonists.
Prior observations have raised the possibility that dihydropyridine (DHP) agonists directly affect the sarcoplasmic reticulum (SR) cardiac Ca(2+) release channel [i.e., ryanodine receptor (RyR)]. In single-channel recordings of purified canine cardiac RyR, both DHP agonists (-)-BAY K 8644 and (+)-SDZ202-791 increased the open probability of the RyR when added to the cytoplasmic face of the chan...
متن کاملCoordinated Incorporation of Skeletal Muscle Dihydropyridine Receptors and Ryanodine Receptors in Peripheral Couplings of BC3H1 Cells
Rapid release of calcium from the sarcoplasmic reticulum (SR) of skeletal muscle fibers during excitation-contraction (e-c) coupling is initiated by the interaction of surface membrane calcium channels (dihydropyridine receptors; DHPRs) with the calcium release channels of the SR (ryanodine receptors; RyRs, or feet). We studied the early differentiation of calcium release units, which mediate t...
متن کاملMolecular interaction of dihydropyridine receptors with type-1 ryanodine receptors in rat brain.
In striated muscles, Ca2+ release from internal stores through ryanodine receptor (RyR) channels is triggered by functional coupling to voltage-activated Ca2+ channels known as dihydropyridine receptors (DHPRs) located in the plasma membrane. In skeletal muscle, this occurs by a direct conformational link between the tissue-specific DHPR (Ca(v)1.1) and RyR(1), whereas in the heart the signal is...
متن کاملInnovative Methodology Deconvolution of confocal images of dihydropyridine and ryanodine receptors in developing cardiomyocytes
Sedarat, Franklin, Eric Lin, Edwin D. W. Moore, and Glen F. Tibbits. Deconvolution of confocal images of dihydropyridine and ryanodine receptors in developing cardiomyocytes. J Appl Physiol 97: 1098 –1103, 2004. First published April 2, 2004; 10.1152/ japplphysiol.00089.2004.—Colocalization of dihydropyridine (DHPR) and ryanodine (RyR) receptors, a key determinant of Ca induced Ca release, was ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2003
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(03)74924-8